Clark J M, Matsumura F
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(1):135-45. doi: 10.1016/0742-8413(87)90156-3.
Ca2+-stimulated ATP hydrolyzing activities (i.e. Na-Ca ATP hydrolysis and Ca + Mg ATP hydrolysis) measured in cockroach brain tissue were highly sensitive to the action of pyrethroid insecticides under in vitro conditions. Non-cyano-containing pyrethroids inhibited Na-Ca ATP hydrolysis to a greater extent than their cyano-containing counterparts. The reverse is true for pyrethroid action on Ca + Mg ATP hydrolysis. Nonmitochondrial Ca + Mg ATP hydrolysis of disrupted synaptosomes was the most sensitive activity examined. Ca2+-stimulated ATP hydrolyzing activities were inhibited in cockroaches poisoned by permethrin in vivo. In vivo poisoning occurred in the presence of a similar amount of bound [14C]permethrin which had been determined to cause a substantial amount of inhibition to Ca2+-stimulated ATP hydrolyzing activities in vitro.
在体外条件下，测定的蟑螂脑组织中钙刺激的ATP水解活性（即钠 - 钙ATP水解和钙 + 镁ATP水解）对拟除虫菊酯类杀虫剂的作用高度敏感。不含氰基的拟除虫菊酯比含氰基的同类物更能抑制钠 - 钙ATP水解。拟除虫菊酯对钙 + 镁ATP水解的作用则相反。破碎突触体的非线粒体钙 + 镁ATP水解是所检测的最敏感活性。在体内被氯菊酯中毒的蟑螂中，钙刺激的ATP水解活性受到抑制。体内中毒发生时，结合的[14C]氯菊酯量与体外已确定能对钙刺激的ATP水解活性产生大量抑制的量相似。
