Sahib I K, Prasada Rao K S, Desaiah D
J Appl Toxicol. 1987 Apr;7(2):75-80. doi: 10.1002/jat.2550070202.
Effects of two classes of pyrethroids, permethrin and resmethrin (type I), cypermethrin and deltamethrin (type II), on basal (calmodulin-deficient) and calmodulin stimulated activities of Ca2+ ATPase and adenylate cyclase from rat brain were studied in vitro. None of the pyrethroids inhibited synaptosomal basal Ca2+ ATPase, but permethrin and deltamethrin inhibited basal adenylate cyclase in the nuclear fraction of a brain homogenate. Both groups of pyrethroids decreased the calmodulin activated Ca2+ ATPase and adenylate cyclase from brain synaptosomes and nuclear fraction. The results indicate that calmodulin-stimulated Ca2+ ATPase is more sensitive to type II pyrethroids and pyrethroids are more effective on calmodulin stimulated enzymes than basal enzyme activities. Since calmodulin, adenylate cyclase and Ca2+ ATPase are known to participate in various brain processes, it is possible that pyrethroids alter neural transmission, however, additional in vivo work would be needed to confirm this possibility.
研究了两类拟除虫菊酯，即氯菊酯和苄呋菊酯（I型）、氯氰菊酯和溴氰菊酯（II型）对大鼠脑基底（钙调蛋白缺陷型）以及钙调蛋白刺激的Ca2+ATP酶和腺苷酸环化酶活性的体外影响。所有拟除虫菊酯均未抑制突触体基底Ca2+ATP酶，但氯菊酯和溴氰菊酯抑制了脑匀浆核部分的基底腺苷酸环化酶。两组拟除虫菊酯均降低了脑突触体和核部分中钙调蛋白激活的Ca2+ATP酶和腺苷酸环化酶活性。结果表明，钙调蛋白刺激的Ca2+ATP酶对II型拟除虫菊酯更敏感，且拟除虫菊酯对钙调蛋白刺激的酶的作用比对基础酶活性更有效。由于已知钙调蛋白、腺苷酸环化酶和Ca2+ATP酶参与各种脑过程，拟除虫菊酯有可能改变神经传递，然而，需要更多的体内研究来证实这种可能性。
