Yablonski M E, Novack G D, Burke P J, Cook D J, Harmon G
Exp Eye Res. 1987 Jan;44(1):49-54. doi: 10.1016/s0014-4835(87)80024-6.
We evaluated the acute effects of installation of 0.5% levobunolol on aqueous humor dynamics in a double-masked study in 18 patients with ocular hypertension. Aqueous flow was measured by fluorophotometry and total outflow facility by tonography. Aqueous flow decreased approximately 29% in the eyes treated with levobunolol. Total outflow facility and episcleral venous pressure measurements were similar in levobunolol-treated eyes and contralateral eyes treated with vehicle. A 36% decrease in intraocular pressure was observed in the levobunolol-treated eyes and a slight intraocular pressure reduction was seen in the vehicle-treated eyes. The results of this study indicate that, similar to timolol, levobunolol lowers intraocular pressure primarily by decreasing aqueous humour production.
我们在一项双盲研究中，对18例高眼压患者使用0.5%左布诺洛尔后房水动力学的急性效应进行了评估。通过荧光光度法测量房水流量，通过眼压描记法测量总房水流出易度。使用左布诺洛尔治疗的眼房水流量减少了约29%。左布诺洛尔治疗眼和使用赋形剂治疗的对侧眼的总房水流出易度及巩膜静脉压测量结果相似。使用左布诺洛尔治疗的眼眼压降低了36%，而使用赋形剂治疗的眼眼压有轻微降低。本研究结果表明，与噻吗洛尔相似，左布诺洛尔主要通过减少房水生成来降低眼压。
