Unit of Antarctic K-route Expedition, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.
Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.
J Biotechnol. 2017 Oct 10;259:15-18. doi: 10.1016/j.jbiotec.2017.08.013. Epub 2017 Aug 14.
Antimicrobial-producing, cold-adapted microorganisms have great potential for biotechnological applications in food, pharmaceutical, and cosmetic industries. Pseudomonas antarctica PAMC 27494, a psychrophile exhibiting antimicrobial activity, was isolated from an Antarctic freshwater sample. Here we report the complete genome of P. antarctica PAMC 27494. The strain contains a gene cluster encoding microcin B which inhibits DNA regulations by targeting the DNA gyrase. PAMC 27494 may produce R-type pyocins and also contains a complete set of proteins for the biosynthesis of adenosylcobalamin and possibly induces plant growth by supplying pyrroloquinoline quionone molecules.
产抗菌物质的、适应寒冷的微生物在食品、制药和化妆品行业的生物技术应用中具有巨大的潜力。南极假单胞菌 PAMC 27494 是一种具有抗菌活性的嗜冷菌,从南极淡水样本中分离得到。本文报道了 P. antarctica PAMC 27494 的完整基因组。该菌株包含一个编码微菌素 B 的基因簇,该基因簇通过靶向 DNA 拓扑异构酶来抑制 DNA 调控。PAMC 27494 可能产生 R 型噬菌体,并含有一套完整的腺苷钴胺素生物合成蛋白,可能通过提供吡咯并喹啉醌分子来诱导植物生长。