法国初级保健中 2016/17 季节性流感疫苗有效性的早期估计。

Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France.

机构信息

Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), F-75012, Paris, France.

出版信息

J Clin Virol. 2017 Oct;95:1-4. doi: 10.1016/j.jcv.2017.08.002. Epub 2017 Aug 9.

DOI:10.1016/j.jcv.2017.08.002

PMID:28818690

Abstract

BACKGROUND

The ongoing 2016/17 influenza epidemic in France is characterized by the circulation of A(H3N2) viruses, known to cause more severe illness among at risk populations.

OBJECTIVES

The purpose of our study was to provide early influenza vaccine effectiveness (IVE) estimates for the ongoing influenza epidemic in France and compare these estimates over the six post-pandemic IVE.

STUDY DESIGN

We used clinical and virological data collected in primary care by the French Sentinelles network. IVE in preventing influenza infection was estimated by the test-negative design method. The screening method was used to estimate IVE in preventing medically-attended influenza-like illness among target groups (<65year with chronic diseases and ≥65 years) since 2010/11 influenza epidemic.

RESULTS

Early IVE estimates in primary care against influenza A(H3N2) were 48% (95% confidence interval (CI): 22-66) overall and 39% (95% CI: -17 to 69) among elderly (aged 65 and older). In comparison to the last six epidemics, 2016/17 early IVE in preventing influenza-like illness among target groups showed VE estimates higher to those reported during the 2011/12 and 2014/15 epidemics.

CONCLUSIONS

The moderate 2016/17 IVE estimates were higher than those estimated during influenza A(H3N2) epidemics with vaccine mismatch.

摘要

背景

法国目前正在经历的 2016/17 年流感疫情的特征是 A(H3N2)病毒的传播，这种病毒已知会导致高危人群病情加重。

目的

我们的研究目的是提供法国当前流感疫情的早期流感疫苗有效性（IVE）估计，并比较这六次大流行后 IVE 的估计值。

研究设计

我们使用法国 Sentinelles 网络在初级保健中收集的临床和病毒学数据。通过测试阴性设计方法估计预防流感感染的 IVE。自 2010/11 年流感疫情以来，使用筛选方法估计针对目标人群（<65 岁有慢性病和≥65 岁）的医学上有意义的流感样疾病的 IVE。

结果

初级保健中针对 A(H3N2)的早期 IVE 估计总体为 48%（95%置信区间[CI]：22-66），老年人（65 岁及以上）为 39%（95% CI：-17 至 69）。与过去六次疫情相比，2016/17 年针对目标人群的流感样疾病的早期 IVE 预防效果估计值高于 2011/12 年和 2014/15 年疫情报告的估计值。