树枝状聚合物与两性离子相遇：开发独特的抗污纳米平台，增强血池、淋巴结和肿瘤 CT 成像。
Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging.
机构信息
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
出版信息
Nanoscale. 2017 Aug 31;9(34):12295-12301. doi: 10.1039/c7nr03940a.
We report the synthesis and characterization of antifouling zwitterion carboxybetaine acrylamide (CBAA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for enhanced CT imaging applications. The CBAA-modified nanodevice displays a better protein resistance property, less macrophage cellular uptake and liver accumulation, and longer blood half-delay time than the PEGylated counterpart material, thereby enabling enhanced blood pool, lymph node, and tumor CT imaging.
我们报告了一种具有抗污性的两性离子羧基甜菜碱丙烯酰胺（CBAA）修饰的树枝状大分子包裹金纳米粒子（Au DENPs）的合成和表征，用于增强 CT 成像应用。与聚乙二醇化的对应材料相比，CBAA 修饰的纳米器件具有更好的蛋白质抗性、更少的巨噬细胞摄取和肝脏积累，以及更长的血液半衰期，从而能够增强血池、淋巴结和肿瘤的 CT 成像。
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