Stuss Michał, Michalska-Kasiczak Marta, Sewerynek Ewa
Department of Endocrine Disorders and Bone Metabolism, Chair of Endocrinology, Medical University of Lodz; The Outpatient Clinic of Endocrinology and Osteoporosis Therapy of the Regional Centre of Menopause and Osteoporosis of the Military Teaching Hospital in Lodz, Poland, Poland.
Endokrynol Pol. 2017;68(4):440-465. doi: 10.5603/EP.2017.0051.
It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium). Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG. This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.
目前认为，甲状腺（TG）的正常功能除了需要碘之外，还需要多种元素，包括硒、铁、锌、铜和钙。在许多情况下，仅充足供应其中一种微量元素（如碘）可能会揭示因其他微量元素（如铁或硒）缺乏而产生的症状。硒被认为是对人体系统内环境稳定至关重要的微量元素，特别是对免疫系统和甲状腺的正常功能而言。流行病学研究结果表明，硒缺乏可能影响全球许多国家多达10亿人。由于补充的微量元素之间存在显著相关性，特定补充的正确顺序也值得强调。例如，已经证明，在地方性甲状腺肿流行地区，过量补充硒可能会增强碘缺乏的影响，而在研究动物中适当补充硒可能会减轻碘过量的后果，预防甲状腺的破坏性炎症病变。本文总结了目前关于硒在甲状腺功能中作用的知识。
