Department of Molecular Biology, University of Texas Southwestern Medical Center , 6000 Harry Hines Boulevard NA5.120F, Dallas, Texas 75390-9148, United States.
Howard Hughes Medical Institute , 6000 Harry Hines Boulevard NA5.120F, Dallas, Texas 75390-9148, United States.
Chem Rev. 2018 Feb 14;118(3):1199-1215. doi: 10.1021/acs.chemrev.7b00145. Epub 2017 Aug 18.
Posttranslational modifications are covalent changes made to proteins that typically alter the function or location of the protein. AMPylation is an emerging posttranslational modification that involves the addition of adenosine monophosphate (AMP) to a protein. Like other, more well-studied posttranslational modifications, AMPylation is predicted to regulate the activity of the modified target proteins. However, the scope of this modification both in bacteria and in eukaryotes remains to be fully determined. In this review, we provide an up to date overview of the known AMPylating enzymes, the regulation of these enzymes, and the effect of this modification on target proteins.
翻译后修饰是对蛋白质进行的共价修饰，通常会改变蛋白质的功能或位置。腺苷酸化是一种新出现的翻译后修饰，涉及将单磷酸腺苷（AMP）添加到蛋白质上。与其他研究更深入的翻译后修饰一样，预计腺苷酸化会调节被修饰靶蛋白的活性。然而，这种修饰在细菌和真核生物中的范围仍有待完全确定。在本综述中，我们提供了已知的腺苷酸化酶、这些酶的调节以及这种修饰对靶蛋白影响的最新概述。
