最大家庭血压是2型糖尿病患者糖尿病肾病的有用指标：加茂川家庭血压（KAMOGAWA-HBP）研究

Maximum home blood pressure is a useful indicator of diabetic nephropathy in patients with type 2 diabetes mellitus: KAMOGAWA-HBP study.

作者信息

Oyabu Chikako, Ushigome Emi, Matsumoto Shinobu, Tanaka Toru, Hasegawa Goji, Nakamura Naoto, Ohnishi Masayoshi, Tsunoda Sei, Ushigome Hidetaka, Yokota Isao, Tanaka Muhei, Asano Mai, Yamazaki Masahiro, Fukui Michiaki

机构信息

1 Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

2 Department of Endocrinology and Metabolism, Kyoto First Red Cross Hospital, Kyoto, Japan.

出版信息

Diab Vasc Dis Res. 2017 Nov;14(6):477-484. doi: 10.1177/1479164117725477. Epub 2017 Aug 18.

DOI:10.1177/1479164117725477

PMID:28819987

Abstract

OBJECTIVE

Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes.

METHODS

In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr).

RESULTS

Multivariate linear regression analyses indicated that mean morning systolic blood pressure ( β = 0.010, p < 0.001) and maximum morning systolic blood pressure ( β = 0.008, p < 0.001) were significantly associated with urine albumin to creatinine ratio. Area under the receiver operating characteristic curve (95% confidence interval) for diabetic nephropathy in mean and maximum morning systolic blood pressure was 0.667 (0.634-0.700; p < 0.001) and 0.671 (0.638-0.703; p < 0.001), respectively.

CONCLUSION

Maximum home systolic blood pressure, as well as mean home systolic blood pressure, was significantly associated with diabetic nephropathy in patients with type 2 diabetes.

摘要

目的

最高家庭收缩压已被证明可预测靶器官损害。我们旨在阐明最高家庭收缩压与尿白蛋白肌酐比值之间的关联，尿白蛋白肌酐比值是2型糖尿病患者早期糖尿病肾病的一个指标。

方法

在1040例患者中，我们评估了平均或最高家庭收缩压与尿白蛋白肌酐比值之间的关系，并比较了平均或最高家庭收缩压对糖尿病肾病（尿白蛋白肌酐比值⩾30 mg/g Cr）的受试者工作特征曲线下面积。

结果

多变量线性回归分析表明，平均晨起收缩压（β = 0.010，p < 0.001）和最高晨起收缩压（β = 0.008，p < 0.001）与尿白蛋白肌酐比值显著相关。平均和最高晨起收缩压对糖尿病肾病的受试者工作特征曲线下面积（95%置信区间）分别为0.667（0.634 - 0.700；p < 0.001）和0.671（0.638 - 0.703；p < 0.001）。