Clark Jaime L, Taylor Carla G, Zahradka Peter
Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg. Canada
Endocr Metab Immune Disord Drug Targets. 2017;17(3):200-206. doi: 10.2174/1871530317666170818120224.
T-cadherin is a unique member of the cadherin family and is primarily expressed in the cardiovascular system. T-cadherin has not been abundantly studied, but the studies conducted to date have explored the impact of this protein on health and the function of organs involved in metabolic regulation.
This article examines the recent knowledge of the ligand partners for T-cadherin and the potential contribution(s) of T-cadherin to cardio-metabolic function.
One significant role for T-cadherin is its ability to bind high molecular weight adiponectin in cardiovascular tissue, thereby mediating the cardio-protective benefits of adiponectin. It also has the ability to bind low-density lipoprotein via its glycosylphosphatidylinositol anchor; however, the exact physiological consequence of this ligand-receptor relationship is not known. T-cadherin appears to affect multiple conditions of cardio-metabolic disease, including atherosclerosis and insulin resistance. Research into T-cadherin has suggested that it may be useful as a diagnostic marker for the early stages of cardiovascular disease. However, with regard to insulin, T-cadherin is necessary for pancreatic insulin secretion, but overexpression of T-cadherin on vascular cells may promote endothelial insulin resistance.
This review provides evidence that T-cadherin has an influential role on key cardiometabolic molecules and warrants further investigation.
T-钙黏蛋白是钙黏蛋白家族的一个独特成员，主要在心血管系统中表达。T-钙黏蛋白尚未得到充分研究，但迄今为止所进行的研究探讨了这种蛋白质对健康以及参与代谢调节的器官功能的影响。
本文考察了关于T-钙黏蛋白的配体伙伴的最新知识以及T-钙黏蛋白对心脏代谢功能的潜在作用。
T-钙黏蛋白的一个重要作用是它能够在心血管组织中结合高分子量脂联素，从而介导脂联素的心脏保护益处。它还能够通过其糖基磷脂酰肌醇锚定结合低密度脂蛋白；然而，这种配体-受体关系的确切生理后果尚不清楚。T-钙黏蛋白似乎会影响多种心脏代谢疾病状况，包括动脉粥样硬化和胰岛素抵抗。对T-钙黏蛋白的研究表明，它可能作为心血管疾病早期阶段的诊断标志物是有用的。然而，对于胰岛素而言，T-钙黏蛋白是胰腺胰岛素分泌所必需的，但T-钙黏蛋白在血管细胞上的过表达可能会促进内皮胰岛素抵抗。
本综述提供了证据表明T-钙黏蛋白对关键的心脏代谢分子具有重要作用，值得进一步研究。
