富血小板纤维蛋白在侵袭性牙周炎三壁骨内缺损治疗中的应用：一项随机对照临床试验。
Autologous Platelet-Rich Fibrin in the Treatment of 3-Wall Intrabony Defects in Aggressive Periodontitis: A Randomized Controlled Clinical Trial.
机构信息
Department of Periodontics, Government Dental College and Research Institute, Fort Bangalore, Karnataka, India.
Department of Endodontics and Conservative Dentistry, Government Dental College and Research Institute.
出版信息
J Periodontol. 2017 Nov;88(11):1186-1191. doi: 10.1902/jop.2017.120661. Epub 2017 Aug 18.
BACKGROUND
Platelet-rich fibrin (PRF) has recently been applied in osseous regeneration. The aim of the present study is to explore the efficacy of PRF in treatment of intrabony defects (IBDs) in aggressive periodontitis.
METHODS
Fifty-four IBDs in 17 patients were treated either with autologous PRF with open flap debridement (OFD) or OFD alone. Clinical and radiologic parameters such as probing depth (PD), clinical attachment level (CAL), IBD depth, and percentage defect change were recorded at baseline and 9 months postoperatively.
RESULTS
Mean PD reduction and mean CAL gain were significantly greater in PRF compared with the control group. Furthermore, a significantly greater percentage of mean bone defect change was found in the PRF group.
CONCLUSION
Within the limits of the present study, there is greater bone fill at sites treated with PRF with conventional OFD than conventional OFD alone.
背景
富血小板纤维蛋白（PRF）最近已应用于骨再生。本研究旨在探讨 PRF 在侵袭性牙周炎中治疗骨内缺损（IBD）的疗效。
方法
17 名患者的 54 个 IBD 分别采用自体 PRF 联合开放式翻瓣术（OFD）或单独 OFD 治疗。记录基线和术后 9 个月时的临床和影像学参数，如探诊深度（PD）、临床附着水平（CAL）、IBD 深度和骨缺损百分比变化。
结果
与对照组相比，PRF 组的 PD 减少平均值和 CAL 获得平均值显著更大。此外，PRF 组的平均骨缺损变化百分比也显著更高。
结论
在本研究范围内，与单独常规 OFD 相比，PRF 联合常规 OFD 治疗的部位有更多的骨填充。
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