Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Al Saraya Str. 11, Manial, Cairo, Egypt.
European Campus Rottal-Inn, Deggendorf Institute of Technology, Deggendorf, Germany.
Clin Oral Investig. 2022 Nov;26(11):6671-6680. doi: 10.1007/s00784-022-04627-2. Epub 2022 Jul 25.
The current randomized controlled trial assessed for the first time the effect of a low-speed platelet-rich fibrin (PRF) with open flap debridement (OFD) versus OFD alone in the treatment of periodontal intra-osseous defects of stage-III periodontitis patients.
Twenty-two periodontitis patients with ≥ 6 mm probing depth (PD) and ≥ 3 mm intra-osseous defects were randomized into test (PRF + OFD; n = 11) and control (OFD; n = 11) groups. Clinical attachment level (CAL)-gain (primary outcome), PD-reduction, gingival recession depth (GRD), full-mouth bleeding scores (FMBS), full-mouth plaque scores (FMPS), radiographic linear defect depth (RLDD), and radiographic bone fill (secondary-outcomes) were examined over 9 months post-surgically.
Low-speed PRF + OFD and OFD demonstrated significant intra-group CAL-gain and PD- and RLDD-reduction at 3, 6, and 9 months (p < 0.01). Low-speed PRF + OFD exhibited a significant CAL-gain of 3.36 ± 1.12 mm at 6 months (2.36 ± 0.81 mm for the control group; p < 0.05), and a significantly greater PD-reduction of 3.36 ± 1.12 mm at 3 months, of 3.64 ± 1.12 mm at 6 months and of 3.73 ± 1.19 mm at 9 months (2.00 ± 0.89 mm, 2.09 ± 1.04 mm, and 2.18 ± 1.17 mm in the control group respectively; p < 0.05). No significant differences were notable regarding GRD, FMPS, FMBS, RLDD, or bone fill between both groups (p > 0.05).
Within the current clinical trial's limitations, the use of low-speed PRF in conjunction with OFD improved CAL and PD post-surgically, and could provide a cost-effective modality to augment surgical periodontal therapy of intra-osseous defects of stage-III periodontitis patients.
Low-speed PRF could provide a cost-effective modality to improve clinical attachment gain and periodontal probing depth reduction with open flap debridement approaches.
本随机对照试验首次评估了低速富血小板纤维蛋白（PRF）联合翻开式清创术（OFD）与单纯 OFD 治疗 III 期牙周炎患者牙周骨内缺损的疗效。
22 名牙周炎患者的探诊深度（PD）≥6mm，骨内缺损≥3mm，随机分为试验组（PRF+OFD；n=11）和对照组（OFD；n=11）。临床附着水平（CAL）增加（主要结局）、PD 减少、牙龈退缩深度（GRD）、全口出血评分（FMBS）、全口菌斑评分（FMPS）、放射线性骨缺损深度（RLDD）和放射骨填充（次要结局）在术后 9 个月进行检查。
低速 PRF+OFD 和 OFD 组在 3、6 和 9 个月时均表现出明显的组内 CAL 增加和 PD 和 RLDD 减少（p<0.01）。低速 PRF+OFD 在 6 个月时表现出 3.36±1.12mm 的显著 CAL 增加（对照组为 2.36±0.81mm；p<0.05），在 3 个月时 PD 减少 3.36±1.12mm，在 6 个月时 PD 减少 3.64±1.12mm，在 9 个月时 PD 减少 3.73±1.19mm（对照组分别为 2.00±0.89mm、2.09±1.04mm 和 2.18±1.17mm；p<0.05）。两组间 GRD、FMPS、FMBS、RLDD 或骨填充无显著差异（p>0.05）。
在当前临床试验的局限性内，低速 PRF 联合 OFD 可改善术后 CAL 和 PD，为 III 期牙周炎患者骨内缺损的牙周手术治疗提供一种具有成本效益的方法。
低速 PRF 可提供一种具有成本效益的方法，通过翻开式清创术改善临床附着体增加和牙周探诊深度减少。
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