From the *Department of Anesthesiology, Cancer Hospital of Harbin Medical University, Harbin; and †Pain Research Institute of Heilongjiang Academy of Medical Sciences, Harbin, China.
Reg Anesth Pain Med. 2017 Sep/Oct;42(5):588-599. doi: 10.1097/AAP.0000000000000647.
To determine whether stellate ganglion block (SGB) treatment exerts protective effects against isoproterenol (ISO)-induced acute myocardial ischemia (AMI) due to its antioxidant effects, we aimed to evaluate the protective effects of different lateral SGB agents on the tissue antioxidant status in ISO-induced AMI in male Sprague-Dawley rats.
The AMI model received an acute ISO overdose to make cardiac ischemia damage at a single dose of 110 mg/kg injected subcutaneously into the rats. The rats in the SGB groups received SGB 15 minutes after ISO treatment. The data were recorded at the following time points: 0 minutes (T0) and 15 minutes after SGB (T1). The levels of cardiac troponin T and cardiac troponin I and the ST-segment depression in lead III were measured at T0 and T1. The values of oxidative production and antioxidative enzymes in the SG and heart were tested.
Stellate ganglion block significantly reduced serum cardiac troponin I and cardiac troponin T levels and mitigated the ST-segment depression and oxidative production levels, but it increased the antioxidative enzymes levels. Right SGB effect was more effective than that of left SGB, in the reduced nitric oxide and malonaldehyde levels, and in the increased superoxide dismutase, glutathione peroxidase, catalase, neuronal nitric oxide synthase, and endothelial nitric oxide synthase levels.
These findings suggest that SGB could have antioxidative effects against AMI, and the protective effect of right SGB was more effective than that of left SGB. Thus, the right SGB could be an effective and safe method of local anesthesia to protect against cardiac damage due to oxidative stress.
为了确定星状神经节阻滞（SGB）是否通过其抗氧化作用对异丙肾上腺素（ISO）诱导的急性心肌缺血（AMI）产生保护作用，我们旨在评估不同外侧 SGB 药物对雄性 Sprague-Dawley 大鼠 ISO 诱导的 AMI 组织抗氧化状态的保护作用。
AMI 模型接受单次皮下注射 110mg/kg ISO 以引起心脏缺血损伤。SGB 组大鼠在 ISO 处理后 15 分钟接受 SGB。在以下时间点记录数据：0 分钟（T0）和 SGB 后 15 分钟（T1）。在 T0 和 T1 测量心肌肌钙蛋白 T 和心肌肌钙蛋白 I 的水平和 III 导联 ST 段压低。测试 SG 和心脏中的氧化产物和抗氧化酶的水平。
SGB 显著降低了血清心肌肌钙蛋白 I 和心肌肌钙蛋白 T 水平，减轻了 ST 段压低和氧化产物水平，但增加了抗氧化酶水平。右侧 SGB 的效果优于左侧 SGB，在降低一氧化氮和丙二醛水平，以及增加超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶、神经元型一氧化氮合酶和内皮型一氧化氮合酶水平方面。
这些发现表明 SGB 可能具有对抗 AMI 的抗氧化作用，右侧 SGB 的保护作用优于左侧 SGB。因此，右侧 SGB 可能是一种有效的局部麻醉方法，可预防氧化应激引起的心脏损伤。
