Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, Box 534, 75121 Uppsala, Sweden.
RISE Bioeconomy, Drottning Kristinas väg 61, 11486, Stockholm, Sweden.
Carbohydr Polym. 2017 Oct 15;174:299-308. doi: 10.1016/j.carbpol.2017.06.073. Epub 2017 Jun 21.
Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented biocompatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material´s potential to maintain a suitable moist environment for different type of wounds. The hydrogels did not affect dermal fibroblasts monolayer cultures upon direct contact, as cell monolayers remained intact after application, incubation and removal of the materials. Inflammatory response studies with blood-derived mononuclear cells revealed the inert nature of the hydrogels in terms of cytokine secretion and reactive oxygen species production. Results highlight the great potential of ion-crosslinked NFC hydrogels for the development of advanced wound dressings, where further functionalization of the material could lead to improved properties towards the healing of specific wound types.
钙离子交联纳米原纤化纤维素 (NFC) 水凝胶被研究为用于伤口愈合敷料的潜在材料。通过流变学和保水试验研究了水凝胶的物理化学性质。选择皮肤细胞和单核细胞进行面向应用的生物相容性研究。NFC 水凝胶呈现出缠结的纤维网络和固态行为。保水试验表明，该材料具有为不同类型伤口保持合适湿润环境的潜力。水凝胶在直接接触时不会影响真皮成纤维细胞单层培养物，因为在应用、孵育和去除材料后，细胞单层仍然完整。用血液来源的单核细胞进行的炎症反应研究表明，水凝胶在细胞因子分泌和活性氧产生方面具有惰性。结果突出了离子交联 NFC 水凝胶在开发先进伤口敷料方面的巨大潜力，进一步对材料进行功能化可能会改善对特定类型伤口愈合的性能。
