Zhu Yingnan, Zhang Jiamin, Yang Jing, Pan Chao, Xu Tong, Zhang Lei
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
J Mater Chem B. 2016 Aug 14;4(30):5105-5111. doi: 10.1039/c6tb00540c. Epub 2016 Jul 18.
Skin traumas are among the most common health problems in the world, and are routinely treated with wound dressings such as bandages and gauze. Traditional dressings are typically made of dry cotton, which tends to adhere to the wound, causing scab formation and bacterial infections. Ideally, a dressing should accelerate wound healing while avoiding any side effects or complications. Recent studies have found that wet dressings, especially hydrogels, can provide a moist environment for wounds that mimics the in vivo environment, thus facilitating debridement of necrotic tissue, enhancing tissue regeneration, and avoiding scab formation. Zwitterionic hydrogels exhibit strong hydration, are biomimetic in nature, and show excellent anti-fouling properties; their resulting high water content, excellent biocompatibility, and negligible interactions with proteins and cells make them ideal wet wound dressings. In this work, we demonstrated that zwitterionic hydrogels, especially poly-carboxybetaine (PCB) hydrogels, can efficiently promote skin wound healing. Skin wounds treated with zwitterionic hydrogels healed significantly better than those treated with PHEMA hydrogels and the commercial product DuoDerm. Moreover, these zwitterionic hydrogels can be easily coated on cotton gauze or bandage pads for easy handling and application. The findings in this work hold great promise for the development of next-generation wound dressings to improve healthcare.
皮肤创伤是世界上最常见的健康问题之一，通常使用绷带和纱布等伤口敷料进行治疗。传统敷料通常由干棉花制成，容易粘连伤口，导致结痂和细菌感染。理想情况下，敷料应加速伤口愈合，同时避免任何副作用或并发症。最近的研究发现，湿性敷料，尤其是水凝胶，可以为伤口提供一个模拟体内环境的湿润环境，从而促进坏死组织的清创，增强组织再生，并避免结痂形成。两性离子水凝胶具有很强的水合作用，本质上具有仿生特性，并表现出优异的抗污性能；其高含水量、出色的生物相容性以及与蛋白质和细胞的相互作用可忽略不计，使其成为理想的湿性伤口敷料。在这项工作中，我们证明了两性离子水凝胶，尤其是聚羧基甜菜碱（PCB）水凝胶，可以有效地促进皮肤伤口愈合。用两性离子水凝胶治疗的皮肤伤口愈合情况明显优于用聚甲基丙烯酸羟乙酯（PHEMA）水凝胶和商业产品多爱肤治疗的伤口。此外，这些两性离子水凝胶可以很容易地涂覆在棉纱布或绷带垫上，便于处理和应用。这项工作的发现为开发下一代伤口敷料以改善医疗保健带来了巨大希望。
