Department of Infectious Diseases, Leiden University Medical Center, Room C5-42, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
U-CyTech Biosciences, Utrecht, The Netherlands.
Infection. 2017 Dec;45(6):917-920. doi: 10.1007/s15010-017-1060-x. Epub 2017 Aug 18.
We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum.
IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies.
我们分析了一位 38 岁患有播散性组织胞浆菌病的女性,以确定其是否存在原发性免疫缺陷。她的血液中没有 IFN-γ 反应,而她的外周血单核细胞 (PBMC) 则有。我们在她的血清中发现了 IgG 类 IFN-γ 自身抗体。
到目前为止,导致感染的 IFN-γ 自身抗体主要在亚洲血统的人群中被检测到,在这些人群中,它与某些 HLA 类型相关。这可能是第一个来自非洲裔的患者,并且没有导致该问题的典型 HLA 类型,该患者产生 IFN-γ 自身抗体。