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[Advances in studies on autoimmune diseases treated by halofuginone].

作者信息

Wang Shi-Qi, Duan Ze-Hua, Zhao Ya-Rong, Dou Huan

机构信息

The State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(11):2042-2045. doi: 10.19540/j.cnki.cjcmm.20170224.006.

DOI:10.19540/j.cnki.cjcmm.20170224.006
PMID:28822145
Abstract

Halofuginone (HF) is a derivative of dichroine which is the extract of traditional Chinese medicine. It is widely used as an efficient anticoccidial drug. Recent studies have found that HF has unique biological activities, showing great potential capacities in the treatment of autoimmune diseases. In the article, we summarized the therapeutic effects of HF in a variety of autoimmune diseases and its mechanism, providing references for further clinical studies of HF.

摘要

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1
[Advances in studies on autoimmune diseases treated by halofuginone].
Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(11):2042-2045. doi: 10.19540/j.cnki.cjcmm.20170224.006.
2
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Halofuginone attenuates intervertebral discs degeneration by suppressing collagen I production and inactivating TGFβ and NF-кB pathway.卤夫酮通过抑制 I 型胶原的产生和失活 TGFβ 和 NF-кB 通路来减轻椎间盘退变。
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Therapeutic effect of Halofuginone on ITP mice by regulating the differentiation of Th cell subsets.卤夫酮通过调节Th细胞亚群分化对免疫性血小板减少症小鼠的治疗作用
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Halofuginone alleviates acute viral myocarditis in suckling BALB/c mice by inhibiting TGF-β1.卤夫酮通过抑制转化生长因子-β1减轻乳鼠BALB/c急性病毒性心肌炎。
Biochem Biophys Res Commun. 2016 Apr 29;473(2):558-64. doi: 10.1016/j.bbrc.2016.03.118. Epub 2016 Mar 25.
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