Department of Clinical Sciences, Division of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Prev Vet Med. 2009 Oct 1;91(2-4):73-84. doi: 10.1016/j.prevetmed.2009.05.003. Epub 2009 Jun 2.
Halofuginone seems to reduce diarrhoea and oocyst shedding in calves with cryptosporidiosis, but provides no complete cure. To develop more precise estimates of the effects of halofuginone on calf cryptosporidiosis, meta-analyses were performed, including studies on prophylactic and therapeutic treatment. Meta-analysis increases statistical power because several trials are evaluated together, increasing the effective sample size and possibility of detecting true effects. In total, 20 cohort or clinical studies (in 16 publications) investigating halofuginone treatment in calves were identified. One study was excluded because treated calves and control calves were not investigated in parallel. Four studies (three publications) were excluded because only abstracts were available. Thus, 15 studies from 12 publications, with 10-311 calves were included for data extraction. Of these, five studies from three publications could not be used for meta-analysis because they did not report the data needed. Effects on infection prevalence, diarrhoeal prevalence and mortality were investigated. For prophylactic treatment, halofuginone had an effect on infection and diarrhoeal prevalence on study days 4 and 7, but the control group had significantly lower infection prevalence than the halofuginone treated group on study day 21. Heterogeneity was detected on study days 14 and 21 and publication bias was detected on study days 7 and 14. Mortality was not affected. For therapeutic treatment, a shortage of studies in combination with heterogeneity made interpretations uncertain, and we could not determine if halofuginone treatment benefits calves.
哈尔福林酮似乎可以减少隐孢子虫病牛的腹泻和卵囊脱落，但不能完全治愈。为了更准确地评估哈尔福林酮对犊牛隐孢子虫病的影响，进行了荟萃分析，包括预防性和治疗性治疗的研究。荟萃分析增加了统计效力，因为可以一起评估多项试验，从而增加了有效样本量和检测真实效果的可能性。总共确定了 20 项研究（在 16 篇出版物中），研究了哈尔福林酮治疗犊牛的效果。有一项研究被排除在外，因为接受治疗的犊牛和对照组犊牛没有进行平行研究。有四项研究（三篇出版物）被排除在外，因为只有摘要可用。因此，从 12 篇出版物中纳入了 15 项研究，其中包括 10-311 头犊牛的数据提取。其中，有五项研究（三篇出版物）无法用于荟萃分析，因为它们没有报告所需的数据。研究了感染率、腹泻率和死亡率的影响。对于预防性治疗，哈尔福林酮对第 4 天和第 7 天的感染和腹泻率有影响，但第 21 天对照组的感染率明显低于哈尔福林酮治疗组。在第 14 天和第 21 天检测到异质性，在第 7 天和第 14 天检测到发表偏倚。死亡率不受影响。对于治疗性治疗，由于研究数量不足和异质性，解释不确定，我们无法确定哈尔福林酮治疗是否有益于犊牛。
