Ho Nguyen Thi Thanh, Kutzner Arne, Heese Klaus
Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea.
Department of Information Systems, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea.
Biol Chem. 2017 Dec 20;399(1):55-61. doi: 10.1515/hsz-2017-0190.
Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating the protein 2, family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity. Insight into the specific regulation of the brain-specific neural master gene |-SRGAP2-FAM72-| may essentially contribute to novel therapeutic approaches to restore or improve higher cognitive functions.
由于社会老龄化，痴呆症对高级认知功能的威胁增加，了解控制大脑记忆和学习过程的分子和细胞事件变得势在必行。在此，我们提出新的主基因对 |-SRGAP2-FAM72-|（SLIT-ROBO Rho GTP酶激活蛋白2，与72序列相似的家族）揭示了神经干细胞（NSC）基因表达调控的新原理，并且在控制人类大脑可塑性方面发挥着独特作用。深入了解大脑特异性神经主基因 |-SRGAP2-FAM72-| 的特定调控可能对恢复或改善高级认知功能的新治疗方法做出重要贡献。
