混杂性、拟态和适应：植物特化代谢的进化。
Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism.
机构信息
Department of Plant Biology, Michigan State University, 612 Wilson Road, East Lansing, MI 48824, USA.
Department of Plant Biology, Michigan State University, 612 Wilson Road, East Lansing, MI 48824, USA; Department of Biochemistry, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.
出版信息
Curr Opin Struct Biol. 2017 Dec;47:105-112. doi: 10.1016/j.sbi.2017.07.005. Epub 2017 Aug 16.
Abstract
Specialized metabolic enzymes and metabolite diversity evolve through a variety of mechanisms including promiscuity, changes in substrate specificity, modifications of gene expression and gene duplication. For example, gene duplication and substrate binding site changes led to the evolution of the glucosinolate biosynthetic enzyme, AtIPMDH1, from a Leu biosynthetic enzyme. BAHD acyltransferases illustrate how enzymatic promiscuity leads to metabolite diversity. The examples 4-coumarate:CoA ligase and aromatic acid methyltransferases illustrate how promiscuity can potentiate the evolution of these specialized metabolic enzymes.
摘要
专业的代谢酶和代谢物多样性通过多种机制进化而来，包括简并性、底物特异性的改变、基因表达的改变和基因复制。例如，基因复制和底物结合位点的改变导致了芥子油苷生物合成酶 AtIPMDH1 从亮氨酸生物合成酶进化而来。BAHD 酰基转移酶说明了酶的简并性如何导致代谢物多样性。4-香豆酸：CoA 连接酶和芳香酸甲基转移酶的例子说明了简并性如何促进这些专门的代谢酶的进化。
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