Department of Applied Mathematics, Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200, Australia; Department of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Firenze, Italy.
Camurus Lipid Research Foundation, Ideon Science Park, 22370 Lund, Sweden.
Colloids Surf B Biointerfaces. 2017 Nov 1;159:394-404. doi: 10.1016/j.colsurfb.2017.07.090. Epub 2017 Aug 5.
Part 1 revisited developments in lipid and surfactant self assembly over the past 40 years [1]. New concepts emerged. Here we explore how these developments can be used to make sense of and bring order to a range of complex biological phenomena. Together with Part 1, this contribution is a fundamental revision of intuition at the boundaries of Colloid Science and Biological interfaces from a perspective of nearly 50 years. We offer new insights on a unified treatment of self assembly of lipids, surfactants and proteins in the light of developments presented in Part 1. These were in the enabling disciplines in molecular forces, hydration, oil and electrolyte specificity; and in the role of non Euclidean geometries-across the whole gammut of physical, colloid and surface chemistry, biophysics and membrane biology and medicine. It is where the early founders of the cell theory of biology and the physiologists expected advances to occur as D'Arcy Thompson predicted us 100 years ago.
第一部分回顾了过去 40 年来脂质和表面活性剂自组装的发展[1]。新的概念出现了。在这里，我们探讨如何利用这些发展来理解和整理一系列复杂的生物学现象。与第一部分一起，这篇文章从近 50 年的角度对胶体科学和生物界面边界的直觉进行了基本修正。我们根据第一部分提出的发展，提供了关于脂质、表面活性剂和蛋白质自组装的统一处理的新见解。这些发展涉及分子力、水合作用、油和电解质特异性方面的使能学科，以及非欧几里得几何在物理、胶体和表面化学、生物物理学和膜生物学和医学等各个领域的作用。这是生物学的细胞理论和生理学家期望取得进展的地方，正如 D'Arcy Thompson 100 年前预测的那样。
