Cancer Research UK Cambridge Centre, Li Ka Shing Centre, University of Cambridge, Cambridge, CB2 0RE, UK.
Cancer Research UK Cambridge Centre, Li Ka Shing Centre, University of Cambridge, Cambridge, CB2 0RE, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Trends Cell Biol. 2017 Nov;27(11):820-832. doi: 10.1016/j.tcb.2017.07.004. Epub 2017 Aug 17.
Cellular senescence is an autonomous tumor suppressor mechanism leading to stable cell cycle arrest. Senescent cells are highly secretory, driving a range of different functions through the senescence-associated secretory phenotype (SASP). Recent findings have suggested that the composition of the SASP is dynamically and spatially regulated and that the changing composition of the SASP can determine the beneficial and detrimental aspects of the senescence program, tipping the balance to either an immunosuppressive/profibrotic environment or proinflammatory/fibrolytic state. Here, we discuss the current understanding of the temporal and spatial regulation of the SASP and the novel finding of NOTCH signaling as a regulator of SASP composition.
细胞衰老（cellular senescence）是一种自主的肿瘤抑制机制，导致细胞周期稳定停滞。衰老细胞具有高度的分泌功能，通过衰老相关分泌表型（SASP）驱动多种不同的功能。最近的研究结果表明，SASP 的组成是动态和空间调节的，并且 SASP 组成的变化可以决定衰老程序的有益和有害方面，使平衡向免疫抑制/促纤维化环境或促炎/纤维溶解状态倾斜。在这里，我们讨论了 SASP 的时间和空间调节的现有理解，以及 NOTCH 信号作为 SASP 组成调节剂的新发现。
