Bodenschatz Nico, Poh Catherine F, Lam Sylvia, Lane Pierre, Guillaud Martial, MacAulay Calum E
British Columbia Cancer Research Centre, Department of Integrative Oncology, Vancouver, British Colu, Canada.
The University of British Columbia, Faculty and Dentistry, Vancouver, British Columbia, Canada.
J Biomed Opt. 2017 Aug;22(8):1-10. doi: 10.1117/1.JBO.22.8.086005.
Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo.
双模式内镜显微镜是一种用于早期癌症检测的诊断工具。它将荧光内镜显微镜的高分辨率细胞核组织对比度与通过漫射光学显微镜获得的深度依赖性上皮后向散射定量相结合。在一项对21名患者的27个口腔病变进行的体内初步成像研究中，我们证明了这两种模式的互补诊断价值，并显示了上皮发育异常程度与光后向散射中相对深度依赖性变化之间的相关性。当两者结合时，这两种模式在体内对中度和重度上皮发育异常均具有诊断敏感性。
