Song Dan-Dan, Wu Ling-Yun
Department of Hematology, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.
Department of Hematology, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Aug;25(4):1223-1226. doi: 10.7534/j.issn.1009-2137.2017.04.046.
Terminal erythroid differentiation and its regulation occurs in the bone marrow specialized structure termed erythroblastic islands. The role of macrophages in erythropoiesis is closely related with the integrity of erythroblastic island, which is reliant on adhesive interactions between erythroid and macrophage cells. In regulating red blood cell homeostasis of adult, macrophages have 2 major roles, retaining erythroblast in bone marrow, controlling the final maturation of erythroblasts into reticulocytes and clearing old erythrocytes. Recent research demonstrated that body can affect erythropoiesis by regulating the function of macrophages in physiological or pathological conditions. This paper review focuses on the new advances of this aspect in recent years, including adhesion factor and regulatory factor between macrophage and red blood cells, role of macrophage in development of red blood cells, effect of macrophage on erythropoiesis in different conditiones and so on.
终末红细胞分化及其调控发生在骨髓中称为成红细胞岛的特殊结构中。巨噬细胞在红细胞生成中的作用与成红细胞岛的完整性密切相关，而成红细胞岛的完整性依赖于红细胞与巨噬细胞之间的黏附相互作用。在调节成年个体的红细胞稳态方面，巨噬细胞具有两个主要作用，即保留骨髓中的成红细胞、控制成红细胞最终成熟为网织红细胞以及清除衰老红细胞。最近的研究表明，机体可在生理或病理条件下通过调节巨噬细胞的功能来影响红细胞生成。本文综述聚焦于近年来这方面的新进展，包括巨噬细胞与红细胞之间的黏附因子和调节因子、巨噬细胞在红细胞发育中的作用、巨噬细胞在不同条件下对红细胞生成的影响等。
