Nicolaides K H, Campbell S, Bradley R J, Bilardo C M, Soothill P W, Gibb D
Lancet. 1987 Apr 25;1(8539):942-5. doi: 10.1016/s0140-6736(87)90292-3.
Humidified oxygen (55%) was administered continuously through a face mask to 5 patients whose pregnancies (4 singleton and 1 twin) were all complicated by severe intrauterine growth retardation, oligohydramnios, high blood-flow impedance in the fetal aorta and umbilical artery, and low mean blood-velocity in the fetal thoracic aorta. All the fetuses were hypoxic and 2 were acidotic. After maternal hyperoxygenation, the fetal pO2 increased to within or near the normal range, and resulted in a sustained increase in the mean blood-velocity in the fetal thoracic aorta. 5 fetuses survived with minimum neonatal morbidity. The effect of maternal hyperoxygenation on the fetal pO2 in such cases may prove to be a useful method of assessing placental function and guiding management.
通过面罩持续向5名孕妇输送55%的湿化氧气，这些孕妇的妊娠（4例单胎和1例双胎）均合并严重的宫内生长受限、羊水过少、胎儿主动脉和脐动脉血流阻抗高以及胎儿胸主动脉平均血流速度低。所有胎儿均缺氧，2例酸中毒。母体进行高氧治疗后，胎儿的pO2升至正常范围或接近正常范围，并导致胎儿胸主动脉平均血流速度持续增加。5名胎儿存活，新生儿发病率最低。在这种情况下，母体高氧治疗对胎儿pO2的影响可能被证明是评估胎盘功能和指导治疗的一种有用方法。
