Laboratoire d'Ecologie des Systèmes Terrestres et Aquatiques, Faculté des Sciences, Université Badji Mokhtar, BP 12, 23000 Sidi Amar, Annaba, Algeria.
Laboratoire de Physiologie Intégrée, Faculté des Sciences, Université de Carthage, Jarzouna, Bizerte 7021, Tunisia.
Environ Toxicol Pharmacol. 2017 Oct;55:51-54. doi: 10.1016/j.etap.2017.08.007. Epub 2017 Aug 12.
Metal ions are of particular importance in nervous system function, notably iron. However, very little has been done to investigate its physiological role in frog peripheral nervous system. The present research aim to evaluate i) the time-effect of sciatic nerve ligation and/or ii) iron sulphate (1.50mg/kg, in lymphatic sac) on frog myelin sheaths. Histological sections following ligation shows degeneration of some fibres with axonal and myelin breakdown associated to a decrease of Schwann cells number following 2h (45.00±0.30, p<0.0001), 24h (28.00±0.020, p<0.0001). Interestingly, iron administration reduces the degeneration of myelin sheaths classically observed in frog ligated sciatic nerve associated with an increase of Schwann cells number (139.00±0.50, p<0.0001). Thus, iron could prevent degeneration or promote regeneration induced by ligation in frog sciatic nerve.
金属离子在神经系统功能中尤为重要，尤其是铁。然而，人们对其在青蛙外周神经系统中的生理作用知之甚少。本研究旨在评估：i）坐骨神经结扎后的时间效应，和/或 ii）硫酸铁（1.50mg/kg，淋巴囊内注射）对青蛙髓鞘的影响。结扎后的组织学切片显示，一些纤维发生变性，轴突和髓鞘断裂，施万细胞数量减少，分别在 2 小时（45.00±0.30，p<0.0001）和 24 小时（28.00±0.020，p<0.0001）后达到最低。有趣的是，铁的给予减少了青蛙结扎坐骨神经中典型观察到的髓鞘变性，同时增加了施万细胞的数量（139.00±0.50，p<0.0001）。因此，铁可以防止青蛙坐骨神经结扎引起的变性或促进其再生。
