Kim Hyewon, Rahaman Khandoker Asiqur, Kwon Jieun, Cho Seohyeon, Chung Seok, Han Hyung-Seop, Kim Yu-Chan
Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Department of Biomicro System Technology, Korea University, Seoul 02841, Republic of Korea.
Biomater Res. 2025 Jul 22;29:0219. doi: 10.34133/bmr.0219. eCollection 2025.
Peripheral nerve injury is a common health issue in modern aging societies, with the only treatment available being autograft transplantation. Unfortunately, autograft is often limited due to donor availability and immune rejection. Additionally, the peripheral nervous system has limited regenerative capacity, making the treatment of peripheral nerve injuries challenging. Metal-based regenerative medicine and tissue engineering strategies provide advanced solutions to the problem. Metal-based biomaterials such as conduits, filaments, alloys, hydrogels, and ceramics can deliver biofunctional metal ions and promote axonal growth and functional recovery. In parallel, metal-based electromagnetic stimulation demonstrates potential for nerve regeneration and inflammation regulation. The potential of metal-based biomaterials in promoting peripheral nerve regeneration highlights the need for further research in tissue engineering and regenerative medicine. However, rapid degradation, long-term biocompatibility, and necessary optimization regarding injury types remain to be explored. This review summarizes the reported metal-based biomaterials utilized in peripheral nerve regeneration research. The aim is to showcase advanced technologies available in the field, which may potentially become a viable alternative to autografts, offering transformative applications in the regenerative medical field.
周围神经损伤是现代老龄化社会中常见的健康问题，目前唯一可用的治疗方法是自体移植。不幸的是，由于供体可用性和免疫排斥反应，自体移植往往受到限制。此外，周围神经系统的再生能力有限，这使得周围神经损伤的治疗具有挑战性。基于金属的再生医学和组织工程策略为该问题提供了先进的解决方案。基于金属的生物材料，如导管、细丝、合金、水凝胶和陶瓷，可以释放生物功能金属离子并促进轴突生长和功能恢复。同时，基于金属的电磁刺激在神经再生和炎症调节方面显示出潜力。基于金属的生物材料在促进周围神经再生方面的潜力凸显了在组织工程和再生医学领域进行进一步研究的必要性。然而，快速降解、长期生物相容性以及针对损伤类型的必要优化仍有待探索。本综述总结了周围神经再生研究中报道的基于金属的生物材料。目的是展示该领域可用的先进技术，这些技术可能成为自体移植的可行替代方案，在再生医学领域提供变革性应用。
