Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, PR China.
Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
Schizophr Res. 2018 May;195:554-559. doi: 10.1016/j.schres.2017.08.020. Epub 2017 Aug 18.
The association between neurocognition and the theory of mind (ToM) abilities during the progression of psychosis is unclear. This study included 83 individuals with attenuated psychosis syndrome (APS), from which 26 converted to psychosis (converters) after a follow up period of 18months. Comprehensive cognitive tests (including MATRICS Consensus Cognitive Battery, Faux-Pas Task, and Reading-Mind-in-Eyes Tasks) were administered at baseline. A structural equation modeling (SEM) analysis was conducted to estimate the effects of neurocognition on the ToM functioning in both APS and healthy controls (HC) datasets. At baseline, the converters and non-converters groups differed significantly on several domains of cognitive performance. The SEM analysis demonstrated that the path from neurocognition to ToM was statistically significant in the APS dataset (p<0.001). However, in the HC dataset, the result of the same analysis was not significant (p=0.117). Positive correlations between neurocognition and ToM were observed, and the most obvious correlations were found in the converters group compared with the non-converters group (p=0.064) and compared with the HC group (p=0.002). The correlation between ToM abilities and neurocognition may be increased during the progression of the condition, especially for individuals who convert to psychosis after a short period.
神经认知与精神病进展过程中的心理理论（ToM）能力之间的关系尚不清楚。本研究纳入了 83 名处于精神病前期综合征（APS）的个体，其中 26 名在 18 个月的随访后转化为精神病（转化者）。基线时进行了综合认知测试（包括 MATRICS 共识认知电池、假过失任务和阅读眼内思维任务）。采用结构方程模型（SEM）分析来估计神经认知对 APS 和健康对照组（HC）数据集的 ToM 功能的影响。基线时，转化组和非转化组在几个认知表现领域存在显著差异。SEM 分析表明，在 APS 数据集中，神经认知到 ToM 的路径具有统计学意义（p<0.001）。然而，在 HC 数据集中，同一分析的结果并不显著（p=0.117）。观察到神经认知与 ToM 之间存在正相关，并且在转化组中与非转化组（p=0.064）和与 HC 组（p=0.002）相比，相关性最明显。在病情进展过程中，神经认知与 ToM 之间的相关性可能会增加，特别是对于在短时间内转化为精神病的个体。
