在人类膳食水平下暴露于铝 60 天会损害大鼠的精子发生和精子质量。
Aluminum exposure for 60days at human dietary levels impairs spermatogenesis and sperm quality in rats.
机构信息
Graduate Program in Biochemistry, Universidade Federal do Pampa, BR 472, Km 592, PO Box 118, Zip Code: 97500-970, Uruguaiana, Rio Grande do Sul, Brazil.
Graduate Program in Biochemistry, Universidade Federal do Pampa, BR 472, Km 592, PO Box 118, Zip Code: 97500-970, Uruguaiana, Rio Grande do Sul, Brazil.
出版信息
Reprod Toxicol. 2017 Oct;73:128-141. doi: 10.1016/j.reprotox.2017.08.008. Epub 2017 Aug 18.
Concerns about environmental aluminum (Al) and reproductive health have been raised. We investigated the effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1 (Lower level) rats were treated orally for 60 days: a) controls - ultrapure water; b) aluminum at 1.5mg/kg bw/day and c) aluminum at 8.3mg/kg bw/day. Experiment 2 (High level) rats were treated for 42 days: a) controls - ultrapure water; b) aluminum at 100mg/kg bw/day. Al decreased sperm count, daily sperm production, sperm motility, normal morphological sperm, impaired testis histology; increased oxidative stress in reproductive organs and inflammation in testis. Our study shows the specific presence of Al in the germinative cells and, that low concentrations of Al in testes (3.35μg/g) are sufficient to impair spermatogenesis and sperm quality. Our findings provide a better understanding of the reproductive health risk of Al.
人们对环境中的铝（Al）和生殖健康表示担忧。我们研究了在人类相关饮食水平和高水平暴露于铝的情况下，铝暴露的影响。实验 1（低水平）中，大鼠经口处理 60 天：a）对照组-超纯水；b）铝 1.5mg/kg bw/天；c）铝 8.3mg/kg bw/天。实验 2（高水平）中，大鼠处理 42 天：a）对照组-超纯水；b）铝 100mg/kg bw/天。铝降低精子计数、每日精子产量、精子活力、正常形态精子，损害睾丸组织学；增加生殖器官的氧化应激和睾丸炎症。我们的研究表明，铝在生殖细胞中存在特异性，而且睾丸中低浓度的铝（3.35μg/g）足以损害精子发生和精子质量。我们的研究结果提供了对铝生殖健康风险的更好理解。
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