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用于骨组织工程的铝/生物塑料支架上的羟基磷灰石涂层。

Hydroxyapatite coating on an aluminum/bioplastic scaffold for bone tissue engineering.

作者信息

Jongprateep Oratai, Jitanukul Nonthaporn, Saphongxay Khotamy, Petchareanmongkol Benjamon, Bansiddhi Ampika, Laobuthee Apirat, Lertworasirikul Amornrat, Techapiesancharoenkij Ratchatee

机构信息

Department of Materials Engineering, Faculty of Engineering, Kasetsart University Bangkok 10900 Thailand

ICE-Matter Consortium, ASEAN University Network/Southeast Asia Engineering Education Development Network (AUN/SEED Net) Bangkok Thailand.

出版信息

RSC Adv. 2022 Sep 21;12(41):26789-26799. doi: 10.1039/d2ra03285f. eCollection 2022 Sep 16.

DOI:10.1039/d2ra03285f
PMID:36320835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9491302/
Abstract

Three-dimensional printing can produce scaffolds with shapes and dimensions tailored for practical clinical applications. Enhanced osteoconductivity of such scaffolds is generally desired. Hydroxyapatite (HA) is an inorganic ceramic that can be used to coat such scaffolds and to accelerate healing during the bone restoration process. In this study, HA-coated aluminum/bioplastic scaffolds were fabricated, and their structural characteristics and osteoconductivity were evaluated. Aluminum/bioplastic scaffolds were fabricated by three-dimensional printing, and HA slurries with solids loadings of 10-20 vol% were used for coating. As solids loadings increased, the thickness of the coating layers slightly increased, whereas pore sizes decreased. The average compressive strength was comparable to that of cancellous bone. Potential osteoconductivity was tested by simulated body fluid immersion for 28 days, and the formation of the HA phase on the surface along with a weight increase indicates the potential bioactivity of the samples.

摘要

三维打印能够制造出形状和尺寸适合实际临床应用的支架。通常希望此类支架具有增强的骨传导性。羟基磷灰石（HA）是一种无机陶瓷，可用于涂覆此类支架并在骨修复过程中加速愈合。在本研究中，制备了HA涂层的铝/生物塑料支架，并对其结构特性和骨传导性进行了评估。铝/生物塑料支架通过三维打印制造，使用固体含量为10 - 20体积%的HA浆料进行涂覆。随着固体含量增加，涂层厚度略有增加，而孔径减小。平均抗压强度与松质骨相当。通过模拟体液浸泡28天测试潜在的骨传导性，表面HA相的形成以及重量增加表明样品具有潜在的生物活性。

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