Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, China; Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, China.
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:438-444. doi: 10.1016/j.pnpbp.2017.08.013. Epub 2017 Aug 18.
Psychomotor retardation (PMR) is one of the core symptoms of major depressive disorder (MDD) and has a specific pathophysiology, but studies of PMR remains sparse. The purpose of this study was to explore the cerebral blood flow (CBF) of PMR in MDD. One-hundred-seven antidepressant-free MDD patients and 48 normal controls (NCs) were recruited for this study. All subjects underwent arterial spin labeling-magnetic resonance imaging (ASL-MRI) for the CBF calculation. MDD patients were divided into the PMR group (N=35) and NPMR (non-PMR) group (N=72) according to the Salpetriere Retardation Rating Scale (SRRS) score. After a baseline MRI scan, patients began to receive antidepressant treatment. Thirty-nine patients (15 PMR, 24 NPMR) who were remitted after 8weeks participated in the follow-up MRI scan. For statistical analysis, subjects with unqualified MRI image and unmatched demographic data were ruled out. Consequently, 30 NCs and 60 patients (30 PMR, 30 NPMR) at baseline as well as 22 patients (11 PMR, 11 NPMR) at follow-up underwent statistical analysis. The PMR group showed significantly decreased CBF in the right primary motor cortex (PMC) at baseline, and the CBF value of the right PMC was significantly correlated with the SRRS score, whereas the CBF of the right PMC was increased in the PMR group at follow-up compared with the baseline in longitudinal comparison. Our findings suggest that the CBF of the right PMC is a potential biomarker of PMR in MDD.
精神运动迟滞（PMR）是重性抑郁障碍（MDD）的核心症状之一，具有特定的病理生理学机制，但目前对 PMR 的研究仍然较少。本研究旨在探讨 MDD 中 PMR 的脑血流（CBF）。本研究纳入了 107 名未服用抗抑郁药的 MDD 患者和 48 名正常对照者（NCs）。所有受试者均接受动脉自旋标记磁共振成像（ASL-MRI）以计算 CBF。根据 Salpetriere 迟滞评分量表（SRRS）评分，MDD 患者分为 PMR 组（N=35）和非 PMR 组（NPMR）（N=72）。基线 MRI 扫描后，患者开始接受抗抑郁治疗。8 周后，39 名患者（15 名 PMR，24 名 NPMR）缓解后参加了随访 MRI 扫描。在统计分析中，排除了 MRI 图像不合格和人口统计学数据不匹配的受试者。因此，30 名 NCs 和 60 名患者（30 名 PMR，30 名 NPMR）在基线以及 22 名患者（11 名 PMR，11 名 NPMR）在随访时进行了统计分析。PMR 组在基线时右侧初级运动皮层（PMC）的 CBF 明显降低，右侧 PMC 的 CBF 值与 SRRS 评分显著相关，而在纵向比较中，PMR 组在随访时右侧 PMC 的 CBF 与基线相比增加。我们的研究结果表明，右侧 PMC 的 CBF 可能是 MDD 中 PMR 的潜在生物标志物。
