Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China; Child Development and Learning Science, Key Laboratory of Ministry of Education, Southeast University, Nanjing 210096, China.
J Affect Disord. 2024 Nov 15;365:509-517. doi: 10.1016/j.jad.2024.08.118. Epub 2024 Aug 24.
Psychomotor retardation (PMR) is a core feature of major depressive disorder (MDD), which is characterized by abnormalities in motor control and cognitive processes. PMR in MDD can predict a poor antidepressant response, suggesting that PMR may serve as a marker of the antidepressant response. However, the neuropathological relationship between treatment outcomes and PMR remains uncertain. Thus, this study examined electrophysiological biomarkers associated with poor antidepressant response in MDD.
A total of 142 subjects were enrolled in this study, including 49 healthy controls (HCs) and 93 MDD patients. All participants performed a simple right-hand visuomotor task during magnetoencephalography (MEG) scanning. Patients who exhibited at least a 50 % reduction in disorder severity at the endpoint (>2 weeks) were considered to be responders. Motor-related beta desynchronization (MRBD) and inter- and intra-hemispheric functional connectivity were measured in the bilateral motor network.
An increased MRBD and decreased inter- and intra-hemispheric functional connectivity in the motor network during movement were observed in non-responders, relative to responders and HCs. This dysregulation predicted the potential antidepressant response.
Abnormal local activity and functional connectivity in the motor network indicate poor psychomotor function, which might cause insensitivity to antidepressant treatment. This could be regarded as a potential neural mechanism for the prediction of a patient's treatment response.
精神运动迟缓（PMR）是重性抑郁障碍（MDD）的核心特征，其表现为运动控制和认知过程异常。MDD 中的 PMR 可预测抗抑郁药反应不佳，表明 PMR 可能是抗抑郁药反应的标志物。然而，治疗结果与 PMR 之间的神经病理学关系尚不确定。因此，本研究探讨了与 MDD 中抗抑郁药反应不良相关的电生理生物标志物。
本研究共纳入 142 名受试者，包括 49 名健康对照（HC）和 93 名 MDD 患者。所有参与者在脑磁图（MEG）扫描期间执行简单的右手视觉运动任务。在终点（>2 周）时表现出疾病严重程度至少降低 50%的患者被认为是应答者。在双侧运动网络中测量运动相关的β去同步化（MRBD）和半球间及半球内功能连接。
与应答者和 HC 相比，非应答者在运动过程中运动网络中的 MRBD 增加和半球间及半球内功能连接减少。这种失调预示着潜在的抗抑郁反应。
运动网络中局部活动和功能连接的异常表明精神运动功能不良，这可能导致对抗抑郁治疗的不敏感。这可以被视为预测患者治疗反应的潜在神经机制。
