体细胞重编程的表观遗传调控。

Epigenetic regulation of somatic cell reprogramming.

机构信息

Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

出版信息

Curr Opin Genet Dev. 2017 Oct;46:156-163. doi: 10.1016/j.gde.2017.07.002. Epub 2017 Aug 17.

DOI:10.1016/j.gde.2017.07.002

PMID:28823984

Abstract

Pluripotent stem cells, having self-renewal capacities and multi-lineage differentiation abilities, offer great potential in disease modeling and therapeutic applications. The successful generation of induced pluripotent stem cells (iPSCs) by the Yamanaka group in 2006 is a milestone event in both reprogramming and stem cell research fields, which makes in vitro somatic cell reprogramming and personalized stem cell therapy feasible. During the past 10 years, several important progresses have been made in uncovering the molecular mechanisms involved in the reprogramming process, which shed light on improving the reprogramming efficiency and iPSC quality. Here, we briefly review the important progresses in the epigenetic regulation including histone and DNA modifications during somatic cell reprogramming.

摘要

多能干细胞具有自我更新能力和多向分化潜能，在疾病建模和治疗应用方面具有巨大的潜力。2006 年，山中伸弥（Yamanaka）小组成功地生成诱导多能干细胞（iPSCs），这是重编程和干细胞研究领域的一个里程碑事件，使得体外体细胞重编程和个性化干细胞治疗成为可能。在过去的 10 年中，人们在揭示重编程过程中涉及的分子机制方面取得了一些重要进展，这为提高重编程效率和 iPSC 质量提供了思路。在这里，我们简要回顾了体细胞重编程过程中组蛋白和 DNA 修饰等表观遗传调控的重要进展。