Zehra Amtuz, Saleh Abdullah Saleh Mohammed, Saboor Muhammad
Department of Pathology, Baqai Medical University, Karachi, Pakistan.
Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Indian J Hematol Blood Transfus. 2017 Sep;33(3):396-401. doi: 10.1007/s12288-016-0736-1. Epub 2016 Oct 31.
Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP). A total of 100 pregnant women were enrolled in the study; 25 were included in the "control group" having normal hematological and biochemical parameters while 75 iron deficient pregnant women were enrolled in the "patient group" with low hematological and biochemical parameters. CRP was done to rule out inflammation and to observe its association with hepcidin. Intravenous iron was administered to the patient group. Post treatment CBC, serum iron, serum ferritin and serum hepcidin were determined. Difference between pre and post treatment hemoglobin, serum iron, serum ferritin and serum hepcidin levels were determined and correlation among them was calculated. Post treatment serum hepcidin levels were significantly higher than pretreatment level ( = 0.001). However, no correlation was seen between serum hepcidin, serum iron, serum ferritin and hemoglobin. Hepcidin levels remain low during pregnancy as there is increased demand for iron in pregnancy. Iron supplementation results in increased hepcidin levels; however no mathematical correlation was found between serum hepcidin level and serum iron profile.
本研究的目的是评估铁疗法对缺铁孕妇血清铁调素水平的影响及其与血红蛋白、血清铁指标和C反应蛋白（CRP）的相关性。共有100名孕妇参与本研究；25名被纳入“对照组”，其血液学和生化指标正常，而75名缺铁孕妇被纳入“患者组”，其血液学和生化指标较低。检测CRP以排除炎症并观察其与铁调素的关联。对患者组给予静脉铁剂治疗。治疗后测定血常规、血清铁、血清铁蛋白和血清铁调素。确定治疗前后血红蛋白、血清铁、血清铁蛋白和血清铁调素水平的差异，并计算它们之间的相关性。治疗后血清铁调素水平显著高于治疗前水平（P = 0.001）。然而，血清铁调素、血清铁、血清铁蛋白和血红蛋白之间未发现相关性。孕期铁调素水平维持在较低水平，因为孕期对铁的需求增加。铁补充剂导致铁调素水平升高；然而，血清铁调素水平与血清铁指标之间未发现数学相关性。
