Aktekin Elif, Bay Ali, Yılmaz Mehmet
Division of Pediatric Hematology, Department of Pediatrics, Gaziantep University, Gaziantep, Turkey.
Division of Hematology, Department of Internal Medicine, Gaziantep University, Gaziantep, Turkey.
Indian J Hematol Blood Transfus. 2017 Sep;33(3):417-420. doi: 10.1007/s12288-016-0737-0. Epub 2016 Oct 21.
Despite the use of new broad-spectrum anti-bacterial and anti-fungal agents, infections still represent the major cause of morbidity and mortality in patients with prolonged neutropenia after intensive chemotherapy. The aim of this study is to assess the effect and safety of granulocyte transfusions (GTs) for the treatment of severe life-threatening infections in pediatric patients with febrile neutropenia. In this study, 13 pediatric patients with high-risk febrile neutropenia, who received 24 GTs, were included. GTs were well tolerated in all patients. Upon 24 h post-transfusion, neutrophil and platelet counts increased significantly, when compared to the baseline values. The clinical response and hematologic response rates were 69.2 % respectively. In conclusion, GT is safe and effective in controlling life-threatening infections. Furthermore, randomized controlled studies with long-term follow-up are needed to assess the exact role of GT in the outcome of patients with neutropenia.
尽管使用了新型广谱抗菌和抗真菌药物，但感染仍是强化化疗后长期中性粒细胞减少患者发病和死亡的主要原因。本研究的目的是评估粒细胞输注（GTs）治疗儿童发热性中性粒细胞减少症严重危及生命感染的疗效和安全性。本研究纳入了13例接受24次GTs的高危发热性中性粒细胞减少症儿童患者。所有患者对GTs耐受性良好。与基线值相比，输血后24小时中性粒细胞和血小板计数显著增加。临床缓解率和血液学缓解率分别为69.2%。总之，GT在控制危及生命的感染方面安全有效。此外，需要进行长期随访的随机对照研究，以评估GT在中性粒细胞减少症患者预后中的确切作用。
