Cugno Chiara, Deola Sara, Filippini Perla, Stroncek David F, Rutella Sergio
Division of Translational Medicine, Clinical Research Center, Sidra Medical and Research Center, Out-Patient Clinic, Al Luqta Street, Education City North Campus, P.O. Box 26999, Doha, Qatar.
Department of Pediatric Hematology and Oncology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
J Transl Med. 2015 Nov 16;13:362. doi: 10.1186/s12967-015-0724-5.
Bacterial and fungal infections continue to pose a major clinical challenge in patients with prolonged severe neutropenia after chemotherapy or hematopoietic stem cell transplantation (HSCT). With the advent of granulocyte colony-stimulating factor (G-CSF) to mobilize neutrophils in healthy donors, granulocyte transfusions have been broadly used to prevent and/or treat life-threatening infections in patients with severe febrile neutropenia and/or neutrophil dysfunction. Although the results of randomized controlled trials are inconclusive, there are suggestions from pilot and retrospective studies that granulocyte transfusions may benefit selected categories of patients. We will critically appraise the evidence related to the use of therapeutic granulocyte transfusions in children and adults, highlighting current controversies in the field and discussing complementary approaches to modulate phagocyte function in the host.
对于化疗后或造血干细胞移植（HSCT）后出现长期严重中性粒细胞减少的患者，细菌和真菌感染仍然是一个重大的临床挑战。随着粒细胞集落刺激因子（G-CSF）的出现，可用于动员健康供体中的中性粒细胞，粒细胞输注已被广泛用于预防和/或治疗严重发热性中性粒细胞减少症和/或中性粒细胞功能障碍患者的危及生命的感染。尽管随机对照试验的结果尚无定论，但先导性研究和回顾性研究表明，粒细胞输注可能使某些特定类型的患者受益。我们将严格评估与儿童和成人使用治疗性粒细胞输注相关的证据，突出该领域当前存在争议的问题，并讨论调节宿主吞噬细胞功能的补充方法。
