Maes Michaël, Vinken Mathieu
Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
J Clin Transl Res. 2017 Feb;3(Suppl 1):189-198. doi: 10.18053/jctres.03.2017S1.004. Epub 2017 Feb 12.
Being critical mediators of liver homeostasis, connexins and their channels are frequently involved in liver toxicity. In the current paper, specific attention is paid to actions of hepatotoxic drugs on these communicative structures. In a first part, an overview is provided on the structural, regulatory and functional properties of connexin-based channels in the liver. In the second part, documented effects of acetaminophen, hypolipidemic drugs, phenobarbital and methapyriline on connexin signaling are discussed. Furthermore, the relevance of this subject for the fields of clinical and toxicology is demonstrated.
作为肝脏内稳态的关键调节因子，连接蛋白及其通道经常参与肝脏毒性反应。在本文中，我们特别关注肝毒性药物对这些通讯结构的作用。第一部分，概述了肝脏中基于连接蛋白的通道的结构、调节和功能特性。第二部分，讨论了对乙酰氨基酚、降血脂药物、苯巴比妥和甲吡咯对连接蛋白信号传导的已记录影响。此外，还证明了该主题在临床和毒理学领域的相关性。
