Serra G, Collu M, Gessa G L
Psychopharmacology (Berl). 1987;91(3):330-3. doi: 10.1007/BF00518186.
The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were antagonized not only by the selective D2 antagonist sulpiride but, unexpectedly, also by the selective D1 antagonist SCH 23390. The results suggest that DA receptors mediating the yawning response are of the D2 type, and that these receptors are connected with D1 receptors in such a way that the blockade of the latter results in the functional inactivation of the former.
研究确定了介导大鼠对多巴胺（DA）激动剂打哈欠反应的DA受体亚型。混合的D1-D2激动剂阿扑吗啡和特异性D2激动剂LY 171555均可诱发打哈欠，但选择性D1激动剂SKF 38393则不能。阿扑吗啡和LY 171555诱导的打哈欠不仅被选择性D2拮抗剂舒必利拮抗，而且出乎意料的是，也被选择性D1拮抗剂SCH 23390拮抗。结果表明，介导打哈欠反应的DA受体是D2型，并且这些受体与D1受体相连，以至于后者的阻断会导致前者功能失活。
