Nepal Manoj, Che Raymond, Ma Chi, Zhang Jun, Fei Peiwen
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Graduate Program of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96813, USA.
Int J Mol Sci. 2017 Aug 19;18(8):1804. doi: 10.3390/ijms18081804.
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.
研究人员投入了大量精力来了解范可尼贫血（FA）背后的分子基础，FA是一种罕见的人类遗传疾病，其特征是癌症发病率极高且伴有许多先天性缺陷。在这些研究中，FA组D2蛋白（FANCD2）已成为FA信号传导的焦点，并在细胞生命的多个方面发挥关键作用，尤其是在细胞对DNA损伤的反应中。在此，我们讨论近期的相关研究，以提供关于FANCD2在DNA损伤反应中作用的最新综述。
