Waeber B, Nussberger J, Brunner H R
Schweiz Med Wochenschr. 1987 Feb 14;117(7):227-38.
Diuretics and beta-blocking agents have been used for several years as first-step drugs in the treatment of hypertension. There is now growing evidence that calcium channel blockers and angiotensin converting enzyme inhibitors can also be administered as first-line antihypertensive agents. These agents offer attractive features from the hemodynamic and metabolic viewpoint and with regard to side effects. Diuretics, beta-blocking agents, calcium channel blockers and angiotensin converting enzyme inhibitors, administered either alone or in combination, normalize blood pressure in almost all hypertensive patients.
利尿剂和β受体阻滞剂作为高血压治疗的一线药物已使用多年。现在越来越多的证据表明，钙通道阻滞剂和血管紧张素转换酶抑制剂也可作为一线抗高血压药物使用。从血流动力学和代谢角度以及副作用方面来看，这些药物具有吸引人的特性。利尿剂、β受体阻滞剂、钙通道阻滞剂和血管紧张素转换酶抑制剂，单独使用或联合使用，几乎能使所有高血压患者的血压恢复正常。
