Detandt Sandrine, Bazan Ariane, Schröder Elisa, Olyff Giulia, Kajosch Hendrik, Verbanck Paul, Campanella Salvatore
Service de Psychologie Clinique et Différentielle, Université Libre de Bruxelles (ULB), Avenue Roosevelt 50 - CP 122, B-1050 Brussels, Belgium.
Service de Psychologie Clinique et Différentielle, Université Libre de Bruxelles (ULB), Avenue Roosevelt 50 - CP 122, B-1050 Brussels, Belgium.
Clin Neurophysiol. 2017 Oct;128(10):1872-1885. doi: 10.1016/j.clinph.2017.07.416. Epub 2017 Aug 5.
Cognitive impairment is a major component in addiction. However, research has been inconclusive as to whether this is also the case for smokers. The present study aims at providing electrophysiological clue for altered inhibitory control in smokers and at investigating whether reduced inhibition was more pronounced during exposure to a smoking cue.
ERPs were recorded during a visual Go-NoGo task performed by 18 smokers and 23 controls, in which either a frequent Go signal (letter "M") or a rare No-Go signal ("letter W") were superimposed on three different long-lasting background contexts: black-neutral, smoking-related and non smoking-related.
(1) Smokers performed worse and had an earlier NoGo-N2 latency as compared to controls and independently of context, suggesting a general inhibition impairment; (2) with smoking-related backgrounds specifically, smokers made fewer mistakes than they did in other contexts and displayed a larger NoGo P3 amplitude.
These data might suggest that background cues related to addiction may help smokers to be more accurate in an inhibition task.
Our results show the classical inhibitory impairment in smokers as compared to non-smokers. However, our data also suggest that a smoking-related background may bolster the inhibitory ability of smokers specifically.
认知障碍是成瘾的一个主要组成部分。然而，关于吸烟者是否也是如此，研究尚无定论。本研究旨在为吸烟者抑制控制改变提供电生理线索，并调查在接触吸烟线索期间抑制能力下降是否更为明显。
对18名吸烟者和23名对照者在视觉Go-NoGo任务中记录事件相关电位（ERP），在该任务中，频繁出现的Go信号（字母“M”）或罕见的No-Go信号（字母“W”）叠加在三种不同的长期背景情境中：黑色中性、吸烟相关和非吸烟相关。
（1）与对照者相比，吸烟者表现更差，且无论情境如何，其NoGo-N2潜伏期更早，提示存在一般性抑制障碍；（2）特别是在与吸烟相关的背景下，吸烟者比在其他情境中犯错更少，且显示出更大的NoGo P3波幅。
这些数据可能表明，与成瘾相关的背景线索可能有助于吸烟者在抑制任务中更准确。
我们的结果显示吸烟者与非吸烟者相比存在典型的抑制障碍。然而，我们的数据也表明，与吸烟相关的背景可能特别增强吸烟者的抑制能力。
