Stellwag F
Wien Klin Wochenschr Suppl. 1979;100:1-20.
The importance to evaluate artificial ventricles for left heart assist under cardiogenic shock conditions is emphasized. The main cardiogenic shock models currently used for assisted circulation research are mentioned. Our own method called selective peripheral coronary embolization is presented in detail with its anatomic, pathologic-histologic and electrocardiographic pattern. Polyester fibrils are embolized selectively to the posterior wall of the heart by direct puncture of the circumflex branch of the left coronary artery. Shock hemodynamics and the effects of circulatory assist by the pneumatically driven ellipsoid ventricle (ELVAD) are demonstrated in 20 acute calf experiments. The artificial ventricle was inserted to the circulation between the natural left ventricle and the thoracic aorta in a paracorporeal and intrathoracic position. ELVAD activation was followed by a significant decrease of left ventricular pressure (-65%) and left atrial pressure (-35%). Cardiac index was increased by 10% and mean aortic pressure by 28% from their shock levels. Hemodynamics in irreversible ventricular fibrillation are analyzed in a calf experiment with a 40 hours survival only with ELVAD assist.
强调了在心源性休克条件下评估用于左心辅助的人工心室的重要性。提及了目前用于辅助循环研究的主要心源性休克模型。详细介绍了我们自己的方法，即选择性外周冠状动脉栓塞，包括其解剖学、病理组织学和心电图模式。通过直接穿刺左冠状动脉回旋支，将聚酯纤维选择性地栓塞到心脏后壁。在20个急性小牛实验中展示了休克血流动力学以及气动椭圆形心室（ELVAD）的循环辅助效果。人工心室在体外和胸腔内位置插入到天然左心室和胸主动脉之间的循环中。ELVAD激活后，左心室压力显著降低（-65%），左心房压力降低（-35%）。心脏指数从休克水平提高了10%，平均主动脉压提高了28%。在仅使用ELVAD辅助存活40小时的小牛实验中分析了不可逆心室颤动中的血流动力学。
