Chung Jun Ku, Plitman Eric, Nakajima Shinichiro, Caravaggio Fernando, Shinagawa Shunichiro, Iwata Yusuke, Gerretsen Philip, Kim Julia, Takeuchi Hiroyoshi, Patel Raihaan, Chakravarty M Mallar, Strafella Antonio, Graff-Guerrero Ariel
Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Multimodal Imaging Group - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
J Alzheimers Dis. 2017;60(2):341-347. doi: 10.3233/JAD-170098.
The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAP+HIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAP+HIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAP+HIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.
由于病因异质性，疑似非阿尔茨海默病病理（SNAP）的临床和结构轨迹仍不明确。对海马体积减小的伴SNAP的遗忘型轻度认知障碍（aMCI）患者（SNAP+HIPPO）和海马体积未减小的伴SNAP的aMCI患者，比较了其基线和两年期间的纵向临床指标（整体认知、日常功能、痴呆症状及学习记忆）以及海马体积轨迹。SNAP+HIPPO组总体基线认知功能更差。纵向来看，SNAP+HIPPO组痴呆临床症状恶化更快。在无淀粉样蛋白病理的情况下，同时存在海马萎缩和皮质代谢减退可能会加重aMCI患者的痴呆症状。
