Bohman Anton, Oscarsson Martin, Holmberg Kenneth, Johansson Leif, Millqvist Eva, Nasic Salmir, Bende Mats
a Department of Otorhinolaryngology , Uppsala University Hospital , Uppsala , Sweden.
b Department of Otorhinolaryngology , Skaraborg Hospital , Skövde , Sweden.
Acta Otolaryngol. 2018 Jan;138(1):46-49. doi: 10.1080/00016489.2017.1366052. Epub 2017 Aug 21.
The aim of this study was to investigate the relative frequency of important symptoms of chronic rhinosinusitis with nasal polyps (CRSwNP), the link between CRSwNP and the lower airways and the importance of smoking in CRSwNP.
Three hundred and sixty-eight patients with CRSwNP and 1349 controls were recruited to the study and underwent a structured interview about symptoms from the upper and lower airways, and about smoking habits. Furthermore, all participants were clinically examined using nasal endoscopy.
Due to interactions between the outcome variables, a multiple logistic regression model was fitted to the data. Nasal secretions, nasal blockage and impaired sense of smell were symptoms associated with CRSwNP. Furthermore, male gender, increasing age and asthma were also associated with the disease. Current smoking was less frequent among patients with CRSwNP.
By comparing symptoms and risk factors of patients with CRSwNP with those of a large population-based control group and testing them in a multiple logistic regression model, we have been able to generate data that address key research interests in CRSwNP.
本研究旨在调查鼻息肉慢性鼻窦炎（CRSwNP）重要症状的相对频率、CRSwNP与下呼吸道之间的联系以及吸烟在CRSwNP中的重要性。
招募368例CRSwNP患者和1349例对照者参与本研究，并就上、下呼吸道症状及吸烟习惯进行结构化访谈。此外，所有参与者均接受鼻内镜临床检查。
由于结果变量之间的相互作用，对数据拟合了多元逻辑回归模型。鼻分泌物、鼻塞和嗅觉减退是与CRSwNP相关的症状。此外，男性、年龄增长和哮喘也与该病相关。CRSwNP患者中当前吸烟者较少见。
通过比较CRSwNP患者与大量基于人群的对照组的症状和危险因素，并在多元逻辑回归模型中进行检验，我们能够生成解决CRSwNP关键研究兴趣的数据。
