Otolaryngology, Hospital de Torres Vedras, Centro Hospitalar do Oeste - Torres Vedras, Rua Dr. Aurélio Ricardo Belo, 2560-364, Torres Vedras, Portugal.
Environmental Health Research Group, CHRC/CEDOC, NOVA Medical School, Lisboa, Portugal.
Sci Rep. 2020 Jul 29;10(1):12674. doi: 10.1038/s41598-020-69693-6.
Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman = 0.517, p = 0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction.
虽然鼻息肉的病理生理学尚未完全阐明，但由于技术限制以及息肉大小可能影响可重复性和记录的有用性的认知，鼻科医生很少使用鼻测压法或最大鼻吸气峰流速（PNIF）对其进行研究。本研究旨在评估鼻测压法和 PNIF 测量值与疾病活动的关系。对 19 例息肉患者、15 例无息肉的慢性鼻窦炎患者和 11 例阴性对照者进行了主动前鼻测压法和 PNIF 检查。对鼻窦炎和息肉患者进行了药物治疗后的重新评估。息肉患者的 Lund-Mackay 评分中位数最高（14 分），Johansen 评分中位数为 1 分。该组患者的 PNIF 及其治疗后变化也最低（治疗前后的中位值分别为 90 L/min 和 0 L/min）。各组之间的鼻腔阻力相似，仅在治疗后与 Johansen 评分相关（Spearman 相关系数为 0.517，p = 0.048）。我们的研究表明，使用鼻测压法和 PNIF 评估息肉患者可能提供有用且可重复的数据。综合考虑几项发现表明，在这些患者中，息肉大小并不是鼻腔功能变化的主要决定因素，需要进一步研究以验证 PNIF 的变化是否反映了鼻窦炎症还是仅仅反映了气道阻塞。
