Ho Wing S V, Kelly Melanie E M
Vascular Biology Research Centre, St George's University of London, London, United Kingdom.
Dalhousie University, Halifax, NS, Canada.
Adv Pharmacol. 2017;80:329-366. doi: 10.1016/bs.apha.2017.05.002. Epub 2017 Jul 3.
Cannabinoids are known to modulate cardiovascular functions including heart rate, vascular tone, and blood pressure in humans and animal models. Essential components of the endocannabinoid system, namely, the production, degradation, and signaling pathways of endocannabinoids have been described not only in the central and peripheral nervous system but also in myocardium, vasculature, platelets, and immune cells. The mechanisms of cardiovascular responses to endocannabinoids are often complex and may involve cannabinoid CB and CB receptors or non-CB receptor targets. Preclinical and some clinical studies have suggested that targeting the endocannabinoid system can improve cardiovascular functions in a number of pathophysiological conditions, including hypertension, metabolic syndrome, sepsis, and atherosclerosis. In this chapter, we summarize the local and systemic cardiovascular effects of cannabinoids and highlight our current knowledge regarding the therapeutic potential of endocannabinoid signaling and modulation.
已知大麻素可调节人体和动物模型中的心血管功能，包括心率、血管张力和血压。内源性大麻素系统的基本组成部分，即内源性大麻素的产生、降解和信号通路，不仅在中枢和外周神经系统中有所描述，在心肌、血管系统、血小板和免疫细胞中也有相关描述。内源性大麻素引起心血管反应的机制通常很复杂，可能涉及大麻素CB1和CB2受体或非CB受体靶点。临床前和一些临床研究表明，针对内源性大麻素系统可以在多种病理生理状况下改善心血管功能，包括高血压、代谢综合征、败血症和动脉粥样硬化。在本章中，我们总结了大麻素对局部和全身心血管的影响，并重点介绍了我们目前对内源性大麻素信号传导和调节的治疗潜力的认识。
