Halliday N J, Dundee J W, Carlisle R J, McClean E
Br J Anaesth. 1987 Apr;59(4):465-7. doi: 10.1093/bja/59.4.465.
Two injectable forms of temazepam, in 90% propylene glycol or 40% salicylic acid, were studied in volunteers, and before surgery in healthy patients. The volunteers also received two forms (capsule and elixir) by mouth. The salicylate preparation was painful on injection and both i.v. formulations caused an unacceptably high incidence of venous thrombosis. Temazepam was detected in plasma earlier following the elixir preparation than the capsule. Plasma concentrations were similar following both injectable preparations. The potency of i.v. temazepam in inducing drowsiness in patients was much less than expected and doses greater than 0.6 mg kg-1 were required to produce adequate sedation. There was a significant reduction in thiopentone induction dose in patients receiving temazepam i.v.
研究人员在志愿者以及健康患者手术前，对两种注射用替马西泮制剂进行了研究，这两种制剂分别含90%丙二醇或40%水杨酸。志愿者还口服了两种剂型（胶囊和酏剂）。水杨酸盐制剂注射时会引起疼痛，并且两种静脉注射制剂导致静脉血栓形成的发生率高得令人无法接受。与胶囊相比，服用替马西泮酏剂制剂后，血浆中更早检测到替马西泮。两种注射制剂后的血浆浓度相似。静脉注射替马西泮诱导患者嗜睡的效力远低于预期，需要大于0.6mg/kg-1的剂量才能产生足够的镇静作用。接受静脉注射替马西泮的患者硫喷妥钠诱导剂量显著降低。
