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miR-17-92 簇高表达在各种肿瘤中的预后价值：来自荟萃分析的证据。

Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis.

机构信息

Department of Urology, Anhui Provincial Children's Hospital, Hefei, China.

Department of Urology, The First Affiliated Hospital of Anhui Medical University (AHMU) and Institute of Urology, AHMU, Hefei, China.

出版信息

Sci Rep. 2017 Aug 21;7(1):8375. doi: 10.1038/s41598-017-08349-4.

DOI:10.1038/s41598-017-08349-4
PMID:28827775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5567103/
Abstract

The prognostic value of miR-17-92 cluster high-expression in various tumors remains controversial. Therefore, we conducted this meta-analysis by searching literatures in PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure to identify eligible studies. Eventually, we analyzed 36 articles that examined 17 tumor types from 4965 patients. Consequently, high-expression of miR-17-92 cluster in various tumors was associated with unfavorable overall survival in both univariate (HR = 2.05, 95%CI: 1.58-2.65, P<0.001) and multivariate (HR = 2.14, 95%CI: 1.75-2.61, P<0.001) analyses. Likewise, similar results were found in different subgroups of country, test method, miR-17-92 cluster component, sample source and size. Additionally, high-expression of miR-17-92 cluster was linked with poor disease-free survival (Univariate: HR = 1.96, 95%CI: 1.55-2.48, P<0.001; Multivariate: HR = 2.18, 95%CI: 1.63-2.91, P<0.001), favorable progression-free survival (Univariate: HR = 0.36, 95%CI: 0.16-0.80, P = 0.012; Multivariate: HR = 1.55, 95%CI: 0.79-3.05, P = 0.201) and poor cancer specific survival in univariate rather than multivariate analyses (Univariate: HR = 1.77, 95%CI: 1.21-2.60, P = 0.004; Multivariate: HR = 1.77, 95%CI: 0.80-3.92, P = 0.160). However, no association of miR-17-92 cluster high-expression was detected with recurrence or relapse-free survival. In summary, this meta-analysis towards high-expression of miR-17-92 cluster has indicated poor prognosis of various cancers. Notably, future studies comprising large cohort size from multicenter are required to confirm our conclusions.

摘要

miR-17-92 簇高表达在各种肿瘤中的预后价值仍存在争议。因此，我们通过检索 PubMed、Embase、Cochrane Library、中国生物医学文献数据库和中国知网，对符合条件的研究进行了荟萃分析。最终，我们分析了 36 篇文献，涉及 4965 名患者的 17 种肿瘤类型。结果表明，miR-17-92 簇在各种肿瘤中的高表达与单因素（HR=2.05，95%CI：1.58-2.65，P<0.001）和多因素（HR=2.14，95%CI：1.75-2.61，P<0.001）分析中的总生存不利相关。同样，在国家、检测方法、miR-17-92 簇组成、样本来源和大小的不同亚组中也发现了类似的结果。此外，miR-17-92 簇的高表达与无病生存不良相关（单因素：HR=1.96，95%CI：1.55-2.48，P<0.001；多因素：HR=2.18，95%CI：1.63-2.91，P<0.001），疾病无进展生存较好（单因素：HR=0.36，95%CI：0.16-0.80，P=0.012；多因素：HR=1.55，95%CI：0.79-3.05，P=0.201），但在单因素而非多因素分析中与癌症特异性生存不良相关（单因素：HR=1.77，95%CI：1.21-2.60，P=0.004；多因素：HR=1.77，95%CI：0.80-3.92，P=0.160）。然而，miR-17-92 簇的高表达与无复发或无病生存无关。总之，这项关于 miR-17-92 簇高表达的荟萃分析表明，各种癌症的预后不良。值得注意的是，需要包含来自多中心的大样本队列的未来研究来证实我们的结论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3196/5567103/8ad4210b0918/41598_2017_8349_Fig8_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3196/5567103/b28f7bf3dd54/41598_2017_8349_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3196/5567103/b4f35f26eef4/41598_2017_8349_Fig5_HTML.jpg
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