College of Biologic Big Data, Yunnan Agricultural University, Kunming 650201, China.
Yunnan Research Institute for Local Plateau Agriculture and Industry, Kunming 650201, China.
Curr Pharm Des. 2017;23(34):5125-5135. doi: 10.2174/1381612823666170822101112.
Danshen (Salvia miltiorrhiza Bunge) is a valued herbal plant in the Traditional Chinese Medicine. The dried root of this plant (Radix Salvia miltiorrhiza), either alone or in combination with other herbal ingredients, has been used for hundreds of years to treat numerous ailments, especially cardiovascular diseases. For the past several decades, many studies have tried to delineate the putative cardioprotective effects of this folk medicine through the lens of modern scientific research. In this review, we have summarized the current knowledge about the pharmacological potentials of danshen. The main focus is laid on the predominant bioactive compounds in danshen, which include phenolic acids and tanshinones. We discussed the absorption and metabolism of these compounds, and examine in detail the cardioprotective mechanisms during atherosclerosis, thrombosis, and myocardial infarction reperfusion.
丹参（Salvia miltiorrhiza Bunge）是中药中的一种珍贵草药植物。这种植物的干根（丹参根），无论是单独使用还是与其他草药成分结合使用，已经使用了数百年，用于治疗许多疾病，特别是心血管疾病。在过去的几十年中，许多研究试图通过现代科学研究的视角来描绘这种民间药物的潜在心脏保护作用。在这篇综述中，我们总结了丹参的药理学潜力的现有知识。主要重点是放在丹参中的主要生物活性化合物上，包括酚酸和丹参酮。我们讨论了这些化合物的吸收和代谢，并详细检查了动脉粥样硬化、血栓形成和心肌梗死再灌注期间的心脏保护机制。
