肺线粒体单胺氧化酶活性的物种差异。

Species differences in lung mitochondrial monoamine oxidase activities.

作者信息

Zychlinski L, Montgomery M R

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):325-8. doi: 10.1016/0742-8413(87)90087-9.

Abstract

Pulmonary mitochondrial monoamine oxidase (MAO) activity was examined in preparations from rat, rabbit and guinea-pig with 12 different amines as substrates: serotonin, norepinephrine, and octopamine (type A specific); tryptamine, benzylamine, 5-methoxytryptamine, 5-methyltryptamine, p-methoxyphenylethylamine, and 3,4-dimethoxyphenethylamine (type B specific); and tyramine, dopamine and 3-methoxytyramine (type A + B specific). The oxidation of type A and type A + B substrates was greater in guinea-pig lung mitochondria than in rat or rabbit preparations. Except for benzylamine, the oxidation of type B substrates was similar in all three species. Benzylamine was not oxidized by guinea-pig lung mitochondria but was actively metabolized by rat and rabbit preparations.

摘要

以12种不同的胺类作为底物，检测了大鼠、兔子和豚鼠肺线粒体单胺氧化酶（MAO）的活性：5-羟色胺、去甲肾上腺素和章鱼胺（A型特异性）；色胺、苄胺、5-甲氧基色胺、5-甲基色胺、对甲氧基苯乙胺和3,4-二甲氧基苯乙胺（B型特异性）；以及酪胺、多巴胺和3-甲氧基酪胺（A型+B型特异性）。A型和A型+B型底物的氧化在豚鼠肺线粒体中比在大鼠或兔子的标本中更显著。除苄胺外，B型底物的氧化在所有三个物种中相似。苄胺不被豚鼠肺线粒体氧化，但被大鼠和兔子的标本积极代谢。